Dextran Modified Silicon Photonic Microring Resonator Sensors
نویسندگان
چکیده
We present a dextran modified silicon microring resonator sensor for high density antibody immobilization. An array of sensors consisting of three sensor rings and a reference ring was fabricated and its surface sensitivity and the limit of detection were obtained using polyelectrolyte multilayers. The mass sensitivity and the limit of detection of the fabricated sensor ring are 0.35 nm/ng mm and 42.8 pg/mm in air, respectively. Dextran modified sensor surface was successfully prepared by covalent grafting of oxidized dextran on 3-aminopropyltriethoxysilane (APTES) modified silicon sensor surface. The antibody immobilization on hydrogel dextran matrix improves 40% compared to traditional antibody immobilization method via APTES and glutaraldehyde linkage. Keywords—Antibody immobilization, Dextran, Immunosensor, Label-free detection, Silicon micro-ring resonator
منابع مشابه
Nonlinear Temperature-Dependent Transfer Characteristics of Silicon Photonic Microring Resonators
We investigate the nonlinear power transfer characteristics of a silicon photonic microring resonator. We show that the microring device behaves as a power limiter if the roll-off tail of its resonance is steeper than a simple Lorentzian lineshape. OCIS codes: (230.4110) Modulators; (230.4555) Coupled Resonators; (200.4650) Optical Interconnects.
متن کاملSensitive on-chip detection of a protein biomarker in human serum and plasma over an extended dynamic range using silicon photonic microring resonators and sub-micron beads.
We demonstrate a three-step assay on a silicon photonic microring resonator-based detection platform that enables the quantitation of the cardiac biomarker C-reactive protein (CRP) over a dynamic range spanning six orders of magnitude. Using antibody-modified microrings, we sequentially monitor primary CRP binding, secondary recognition of bound CRP by a biotinylated antibody, and tertiary sign...
متن کاملTunable complex-valued multi-tap microwave photonic filter based on single silicon-on-insulator microring resonator.
A complex-valued multi-tap tunable microwave photonic filter based on single silicon-on-insulator microring resonator is presented. The degree of tunability of the approach involving two, three and four taps is theoretical and experimentally characterized, respectively. The constraints of exploiting the optical phase transfer function of a microring resonator aiming at implementing complex-valu...
متن کاملPhotonic crystal microring resonator for label-free biosensing.
A label-free optical biosensor based on a one-dimensional photonic crystal microring resonator with enhanced light-matter interaction is demonstrated. More than a 2-fold improvement in volumetric and surface sensing sensitivity is achieved compared to conventional microring sensors. The experimental bulk detection sensitivity is ~248nm/RIU and label-free detection of DNA and proteins is reporte...
متن کاملIII–V-on-Silicon Photonic Integrated Circuits for Spectroscopic Sensing in the 2–4 μm Wavelength Range
The availability of silicon photonic integrated circuits (ICs) in the 2-4 μm wavelength range enables miniature optical sensors for trace gas and bio-molecule detection. In this paper, we review our recent work on III-V-on-silicon waveguide circuits for spectroscopic sensing in this wavelength range. We first present results on the heterogeneous integration of 2.3 μm wavelength III-V laser sour...
متن کامل